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β-Amyloid (25-35)

🥰Excellent
Catalog No. T14284Cas No. 131602-53-4
Alias β-Amyloid peptide(25-35), Aβ25-35, Amyloid beta-peptide(25-35)

β-Amyloid (25-35) (Aβ25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.

β-Amyloid (25-35)

β-Amyloid (25-35)

🥰Excellent
Purity: 97.91%
Catalog No. T14284Alias β-Amyloid peptide(25-35), Aβ25-35, Amyloid beta-peptide(25-35)Cas No. 131602-53-4
β-Amyloid (25-35) (Aβ25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.
Pack SizePriceAvailabilityQuantity
1 mg60 €In Stock
5 mg179 €In Stock
10 mg274 €In Stock
25 mg493 €In Stock
50 mg714 €In Stock
100 mg1.007 €In Stock
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Purity:97.91%
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Product Introduction

Bioactivity
Description
β-Amyloid (25-35) (Aβ25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.
In vitro
The amino acid sequence of β-Amyloid (25-35) is NH2-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-COOH, where the first Gly represents the amino acid 25 and the last Met represents the amino acid 35 and it is also investigated in gel state for the first time. Amyloid beta-peptide(25-35) induces apoptotic effects on isolated brain mitochondria and the redox state of methionine-35, plays a key role in the induction of programmed cellular death pathways and toxic events[2]. Comparative studies are also carried out using vibrational absorption and ECD. The conformational preference of Aβ(25-35) peptide film is also investigated using vibrational absorption and VCD spectroscopy[1].
In vivo
The Alzheimer' s disease (AD) model group present with spatial learning and memory impairments. CDS and donepezil administration significantly ameliorate the Aβ25–35 peptide-induced memory impairment in both Morris water maze (P<0.05) and passive avoidance task (P<0.01) compared to the AD model group[3]. Rats are injected with β-Amyloid (25-35) intracerebroventricularly and compound Danshen (CDS) are subsequently administered once daily for 23 days. Rats' behavior is monitored using Morris water maze and passive avoidance. Real time PCR and Western blotting are used in determining amyloid precursor protein (APP), β-site APP cleaved enzyme-1(BACE1), Presenilin-1 (PS1), Insulin-degrading enzyme (IDE) and neprilysin (NEP) in hippocampus.
Aliasβ-Amyloid peptide(25-35), Aβ25-35, Amyloid beta-peptide(25-35)
Chemical Properties
Molecular Weight1060.27
FormulaC45H81N13O14S
Cas No.131602-53-4
SmilesCCC(C)C(NC(=O)C(NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)CN)C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(O)=O
Relative Density.1.249g/cm3
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 3.33 mg/mL (3.14 mM), Sonication is recommended.
DMSO: 97 mg/mL (91.49 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM0.9432 mL4.7158 mL9.4316 mL47.1578 mL
DMSO
1mg5mg10mg50mg
5 mM0.1886 mL0.9432 mL1.8863 mL9.4316 mL
10 mM0.0943 mL0.4716 mL0.9432 mL4.7158 mL
20 mM0.0472 mL0.2358 mL0.4716 mL2.3579 mL
50 mM0.0189 mL0.0943 mL0.1886 mL0.9432 mL

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